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Mivebresib

CAS No. : 1445993-26-9

MCE 國際站：Mivebresib

產(chǎn)品活性：Mivebresib (ABBV-075) 是一種有效的，口服活性的溴結(jié)構(gòu)域和末端結(jié)構(gòu)域 (BET) 抑制劑。Mivebresib 與 BRD4 結(jié)合的 K_i 為 1.5 nM。

研究領(lǐng)域：Epigenetics  |  Apoptosis

作用靶點：Epigenetic Reader Domain  |  Apoptosis

In Vitro: Mivebresib inhibit DHT-stimulated transcription of AR target genes without significant effect on AR protein expression. In addition to blocking the transcription activation downstream of AR, Mivebresib is also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins.

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