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MCB-613

CAS No. : 1162656-22-5

MCE 國際站：MCB-613

產(chǎn)品活性：MCB-613 是一種有效的類固醇受體共激活因子 (SRC) 小分子“刺激物" (SMS)，超刺激 SRCs 的轉(zhuǎn)錄活性。 MCB-613 增加了 SRC 與其他共激活因子的相互作用，并顯著誘導(dǎo) ER 應(yīng)激與活性氧 (ROS) 的產(chǎn)生相結(jié)合。 MCB-613 是一種 SMS，通過過度刺激 SRC 致癌程序，靶向癌基因用作抗癌活性分子。

研究領(lǐng)域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶點(diǎn)：Reactive Oxygen Species

In Vitro: MCB-613 (6-8 μM; 24 hours) activates endogenous MMP13 mRNA expression in MDA-MB-231 cells.
MCB-613 (2-10 μM; 4 hours) leads to proteasome dysfunction and ER stress, the induction of the markers for unfolded protein response (UPR), including the phosphorylation of eIF2α and IRE1α as well as the induction of ATF4 protein expression.
MCB-613 (0-7 μM; 4 hours) affects SRC-3 KO and WT HeLa cell viability, SRC-3 WT HeLa cell is more affected by MCB-613 compared with KO cells.

In Vivo: MCB-613 (intravenous injection; 20 mg/kg; 3 times/week; 7 weeks) significantly and dramatically stalls the growth of the tumor compared with the control group and causes no obvious animal toxicity

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