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商品信息

產品英文名稱	Mouse Oncostatin M Protein
產品中文名稱	重組小鼠腫瘤抑制素M（OSM）
別名	OSM; OS-M; Oncostatin M

商品屬性

標簽	無標簽
表達宿主	大腸桿菌
種屬	小鼠
序列	氨基酸序列來源于：重組小鼠腫瘤抑制素M（OSM） (P53347) (Ala24-Arg206) 表達的蛋白片段。
活性	Testing in Progress
蛋白長度	重組小鼠腫瘤抑制素M（OSM）由183個氨基酸組成，預測分子量為20.39 KD。
純度	> 99% ，使用SDS-PAGE檢測
特點&優(yōu)勢	通過LAL法測定，每微克蛋白里內毒素含量<1.0>
產品形式	凍干粉，凍干緩沖液為無菌的20 mM Tris，150 mM NaCl，pH 7.4。
基因ID	18413
蛋白序列鏈接	/uniprotkb/P53347/entry
使用中注意事項	開蓋使用前，請先離心。本產品為凍干粉，推薦用該產品配套的Reconstitution Buffer進行復溶，且濃度不低于100 µg/mL。客戶可根據后續(xù)的實驗需求，進行進一步的稀釋。
保存建議	本產品為凍干粉形式，建議：將凍干粉產品保存于-20℃以下的干燥環(huán)境中。本產品溶解之后，可在4℃保存2-7天，長期使用請置于-20℃以下。為長期保存，推薦添加載體蛋白（0.1% HAS/BSA或11%FBS），并酌情分裝保存，避免反復凍融。
運輸條件	冰袋運輸（藍冰）
警告	本文列出的產品僅供研究使用，不適用于人類或臨床診斷。我們產品所推薦應用，不是建議使用我們的產品去違反任何或許可證。對于使用本產品可能發(fā)生的侵權或其他違規(guī)行為，我們不承擔任何責任。

附加信息

背景

Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠａnd typeⅡ both of which share the similarity of containing protein gp130 and takes part in many bio metabolism processes including liver development, hematopoiesis, inflammation, bone formation, and destruction and possibly CNS development. Oncostatin M (OSM) was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6, and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degrees but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-terminal most 31 amino acids produces the fully active 196 residue form.

圖片及說明