目錄:亞科因(武漢)生物技術有限公司>>細胞因子及蛋白>>細胞因子>> Human NRG1 Beta1 Protein重組人神經調節(jié)蛋白1-β1(NRG1-β1)
產品英文名稱 | Human NRG1 Beta1 Protein |
產品中文名稱 | 重組人神經調節(jié)蛋白1-β1(NRG1-β1) |
別名 | ARIA; NRG1; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor |
標簽 | 無標簽 |
表達宿主 | 大腸桿菌 |
種屬 | 人 |
序列 | 氨基酸序列來源于:重組人調蛋白-1 β1 Q02297 (S20-K241) 表達的蛋白片段。 |
活性 | 通過其誘導MCF-7細胞增殖的能力來測定。該效應的ED50為0.6730 ng/mL。 |
蛋白長度 | 重組人調蛋白-1 β1由220個氨基酸組成,預測分子量為24.04 KD。 |
純度 | > 99% ,使用SDS-PAGE檢測 |
特點&優(yōu)勢 | 通過LAL法測定,每微克蛋白里內毒素含量<1.0>1.0> |
產品形式 | 凍干粉,凍干緩沖液為無菌的20 mM Tris,150 mM NaCl,pH 7.4。 |
基因ID | 142445 |
蛋白序列鏈接 | NRG1 - Pro-neuregulin-1, membrane-bound isoform - Homo sapiens (Human) | UniProtKB | UniProt |
使用中注意事項 | 開蓋使用前,請先離心。本產品為凍干粉,推薦用該產品配套的Reconstitution Buffer進行復溶,且濃度不低于100 µg/mL??蛻艨筛鶕罄m(xù)的實驗需求,進行進一步的稀釋。 |
保存建議 | 本產品為凍干粉形式,建議:將凍干粉產品保存于-20℃以下的干燥環(huán)境中。本產品溶解之后,可在4℃保存2-7天,長期使用請置于-20℃以下。為長期保存,推薦添加載體蛋白(0.1% HAS/BSA或10%FBS),并酌情分裝保存,避免反復凍融。 |
運輸條件 | 冰袋運輸(藍冰) |
警告 | 本文列出的產品僅供研究使用,不適用于人類或臨床診斷。我們產品所推薦應用,不是建議使用我們的產品去違反任何或許可證。對于使用本產品可能發(fā)生的侵權或其他違規(guī)行為,我們不承擔任何責任。 |
背景 | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44 kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. |
Fig.Human NRG1 Beta1 Protein