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(±)-Equol

產(chǎn)品活性：(±)-Equol 是 equol 的外消旋體。(±)-Equol 對(duì) ERα 和 ERβ 的 EC₅₀s of 分別為 200 和 74 nM。Equol是大豆異黃酮黃豆苷和大豆黃素的代謝產(chǎn)物。

研究領(lǐng)域：Vitamin D Related/Nuclear Receptor  |  Metabolic Enzyme/Protease

作用靶點(diǎn)：Estrogen Receptor/ERR  |  Drug Metabolite

結(jié)構(gòu)分類(lèi)：酚類(lèi)  |  單酚類(lèi)  |  酚類(lèi)  |  多酚類(lèi)  |  結(jié)構(gòu)分類(lèi)

來(lái)源：植物  |  豆科  |  大豆

In Vitro: Equol is first isolated and identified from pregnant-mares' urine and later found in the urine of the goat, cow, hen and sheep. Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers. S-equol is the exclusive product of human intestinal bacterial synthesis from soy isoflavones and both enantiomers are bioavailable. S-equol has a high affinity for estrogen receptor beta (K_i=0.73 nM), whereas R-equol is relatively inactive. Equol could promote the proliferation and differentiation of rat osteoblasts through activating the ER-PKCα-related signaling pathway. The alkaline phosphatase activity also increases significantly in all of the equol and 17β-estradiol (E2 ) groups. Equol also significantly elevates the osteocalcin levels.

In Vivo: Equol is a modest natriuretic and vasorelaxant agent in the rat. Orally administered equol is about 8-fold less potent than orally administered furosemide. In isolated aortic rings precontracted by administration of phenylephrine, administration of equol relaxes the contracted aorta (concentration for half-maximal activity 58.9±16 μM). Equol possesses anticancer activity that suppresses tumor formation via apoptosis induction in rats with mammary gland tumors. In addition, equol shows a hepatic protective effect by acting as an antioxidant and by reducing apoptosis.

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