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Iscalimab

CAS No. : 2031153-61-2

產(chǎn)品活性：Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (K_D: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases.

研究領(lǐng)域：Apoptosis

作用靶點：TNF Receptor

In Vitro: Iscalimab (0.01-1 μg/mL, overnight) blocks rCD154-induced TNF production by primary monocyte-derived dendritic cells (moDCs), with an IC₅₀ of 0.04 μg/mL.
Iscalimab (3 days) inhibits rCD154-induced proliferation of PBMCs from humans, rhesus and cynomolgus animals with IC₅₀s of 0.02, 0.03, and 0.01 μg/mL, respectively.
Iscalimab bind CD40 on B cells from humans, rhesus and cynomolgus animals with EC50 values of approximately 0.2 μg/mL.
Iscalimab (2 μg/mL, 3 h) is internalized by B cells in a CD40-dependent manner.

In Vivo: Iscalimab (150 mg/kg/week, s.c, for 13 weeks) is well tolerated and does not cause any dose-limiting toxicity in rhesus monkeys.
Iscalimab (10 mg/kg, i.v.) completely inhibits T cell-dependent antibody response in Rhesus monkeys.
Iscalimab (30 mg/kg, i.v.) prolongs allograft survival in kidney transplant cynomolgus.

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