MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。

Bleomycin sulfate

CAS No. : 9041-93-4

產(chǎn)品活性：Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic.

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Anti-infection

作用靶點：DNA/RNA Synthesis  |  Antibiotic

結(jié)構(gòu)分類：抗生素  |  其他類  |  結(jié)構(gòu)分類

In Vitro: Bleomycin (BLM) sulfate is chosen as the best-studied micronucleus (MN) inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation.
The IC₅₀ value of Bleomycin sulfate for UT-SCC-19A cell line is 4.0±1.3 nM. UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin (BLM); IC₅₀ values are 14.2±2.8 nM and 13.0±1.1 nM, respectively.
Bleomycin sulfate (50, 100?μM; for 24, 48?h) induce pulmonary fibrosis in RLE-6TN cell (50?μM) and A549 cell (100?μM).

In Vivo: Bleomycin sulfate treatment (3.5-4.0?mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study.
Bleomycin sulfate (3.5-4.0?mg/kg;?intra-tracheal) produces a statistically significant increase in lung?hydroxyproline?levels, and also increases right caudal?lung lobe?mass.
Bleomycin sulfate (intratracheal instillation; 5.0?mg/kg/day) induces pulmonary fibrosis in eighty 8-week-old male BALB/c mice with weight about 20-30?g. Bleomycin induces the expression levels of α-SMA and collagen I.
Bleomycin sulfate (intratracheally; 2.5?mg/kg; 1.25?mg/ml, approximately 50?µl per mouse) induces pulmonary fibrosis in male C57BL/6 mice (8?weeks old, average weight approximately 24.5?g).

相關(guān)產(chǎn)品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  (1R,2S,7R)-Sitafloxacin-d₄ (hydrochloride)  |  Doxorubicin-¹³C,d₃ (TFA)  |  Antibiotic A-33853  |  Sulbactam-d₂ (sodium)  |  IBU-DC Phosphoramidite  |  Azlocillin sodium salt  |  2,4-D sodium salt  |  Thailanstatin D  |  Toyocamycin  |  Hispolon  |  Carboplatin-d₄  |  SPR206 acetate  |  Caracemide  |  Doxycycline calcium  |  Farudodstat  |  Staurosporine  |  Dihydrostreptomycin sulfate  |  WX-081  |  SQ109  |  Neomycin sulfate  |  DNA31  |  Concanavalin A  |  Framycetin  |  Colistin sulfate  |  Amphotericin A  |  2'-OMe-Ac-C Phosphoramidite  |  L-Lactic acid-2-¹³C₁  |  Griseofulvin-d₃  |  Monensin sodium salt  |  (R)-10,11-Dehydrocurvularin

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領(lǐng)；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā)、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業(yè)技術(shù)服務(wù)；
•   設(shè)有專業(yè)的實驗中心和嚴格的質(zhì)控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質(zhì)檢報告，確保產(chǎn)品的高純度、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團隊跟蹤新的制藥及生命科學研究進展，為您提供*新的活性化合物；
•   與世界各大制藥公司及*科研機構(gòu)建立了長期的合作。