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Beraprost sodium

CAS No. : 496807-11-5

產(chǎn)品活性：Beraprost sodium, a prostacyclin analog, is a stable and orally active proagent of PGI2. Beraprost sodium is a potent vasodilator, has the potential for pulmonary arterial hypertension treatment through expanding renal vessels, improving microcirculation.

研究領(lǐng)域：GPCR/G Protein

作用靶點(diǎn)：Prostaglandin Receptor

In Vitro: Beraprost sodium (0.1, 1.0, and 10.0?μM; 24 hours) treatment leads to a significant increase in the number of tube formation, BPS plays an important role on angiogenic activity. Beraprost sodium (0.1, 1.0, and 10.0?μM; 24 hours) treatment let VE-cadherin at regions of cell–cell contact becomes more abundant and the morphology of endothelial cells tends to be normal compared with those cultured under hypoxia conditions.

In Vivo: Beraprost sodium (oral adminstration; 0.6?mg/kg; once daily; 3 or 7 days) can mitigate the development of renal interstitial fibrosis, decrease renal oxidative stress through its potential vasodilation effect, and further prevent renal interstitial fibrosis.

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