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Ertapenem disodium

CAS No. : 153832-38-3

產(chǎn)品活性：Ertapenem (MK-0826) disodium is a broad spectrum and long acting β-lactam antibiotic. Ertapenem disodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem disodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract.

研究領(lǐng)域：Anti-infection

作用靶點(diǎn)：Bacterial  |  Antibiotic

In Vitro: Ertapenem disodium (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC₉₀ of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively.

In Vivo: Ertapenem disodium (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection, S. aureus thigh tissue infection model) shows > 3 log₁₀ CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log₁₀ CFU eliminated at 2 mg/kg.
Ertapenem disodium (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED₅₀s of <0.25 mg/kg/dose.

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