目錄:MedChemExpress LLC>>生化試劑>> SPH5030 | MCE
| CAS | 2364326-23-6 | 分子量 | 582.63 |
|---|---|---|---|
| 分子式 | C??H??FN?O? | 供貨周期 | 現(xiàn)貨 |
| 貨號 | HY-143319 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
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CAS No. : 2364326-23-6
產(chǎn)品活性：SPH5030 is a selective and irreversible HER2 inhibitor. SPH5030 inhibits HER2WT and EGFRWT with IC50s of 3.51 and 8.13 nM, respectively. SPH5030 shows excellent activities against HER2 mutants. SPH5030 can be used for the research of cancer.
研究領(lǐng)域：Others
作用靶點(diǎn)：Others
In Vitro: SPH5030 (0-10 μM; 72 h) shows anti-proliferation activities against tumor cell lines.
In Vivo: SPH5030 (5-40 mg/kg; p.o. once per day for 13 or 21 days) shows in vivo antitumor efficacy in mice with xenograft tumor models.
＜ｍｅｔａ http-equiv="Content-Type" content="text/html; charset=utf-8" />| Mice IV 3 mg/kg | Mice PO 10 mg/kg | Rats IV 3 mg/kg | Rats PO 6 mg/kg | |
| CL (L/kg·h) | 0.70±0.20 | 0.78±0.13 | ||
| t1/2 (h) | 3.76±0.15 | 3.60±0.59 | 4.56±0.20 | 4.38±0.35 |
| Vss (L/kg) | 2.96±0.96 | 3.55±0.64 | ||
| Cmax (μg/mL) | 1.90±0.14 | 0.76±0.33 | ||
| tmax (h) | 2.67±1.15 | 3.33±1.15 | ||
| AUC0-t (h·μg/mL) | 13.07±0.48 | 5.47±2.82 | ||
| F (%) | 87.66 | 71.35 |
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