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5α-Pregnane-3β,6α-diol-20-one

CAS No. : 21853-11-2

產(chǎn)品活性：5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

研究領域：Metabolic Enzyme/Protease

作用靶點：Drug Metabolite

結構分類：甾體類  |  結構分類

In Vitro: Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity.

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