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[Leu5]-Enkephalin

CAS No. : 58822-25-6

產(chǎn)品活性：[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

研究領(lǐng)域：GPCR/G Protein  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶點(diǎn)：Opioid Receptor  |  Endogenous Metabolite

結(jié)構(gòu)分類：酚類  |  單酚類  |  其他類  |  結(jié)構(gòu)分類

In Vitro: Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. K_i=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas.Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain.

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