Lactate | 乳酸

MCE 國際站：Lactate

中文名：乳酸

CAS：50-21-5

品牌：MedChemExpress (MCE)

存儲條件：Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：乳酸（Lactate acid）是糖酵解的產(chǎn)物。乳酸是由于體內(nèi)收縮骨骼肌缺氧而產(chǎn)生的，可以在完-全有氧條件下去除。乳酸可以作為危重患者的血流動力學(xué)指標(biāo)^[1][2]。

體外：Lactate (Lactic acid；20 mM；24、48 小時) 導(dǎo)致細(xì)胞增殖和遷移顯著減少，作用并將細(xì)胞代謝轉(zhuǎn)變?yōu)檠趸姿峄痆1]。 Lactate (20 mM；24 小時) 顯示 MCT1 和 HCAR1 的蛋白質(zhì)和 mRNA 表達(dá)水平增加[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)：Lactate (Lactic acid；1.6 g/kg；皮下注射；每天一次；第 8 天至 30 天) 在 MC38 結(jié)腸癌模型中顯示出 CD8+ T 細(xì)胞依賴性腫瘤生長抑制作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 mice with MC38 colon cancer cells[2] Dosage: 1.6 g/kg Administration: Subcutaneous; daily from Day 8 to 30 days Result: Significantly suppressed tumor growth. Clinical Trial

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研究領(lǐng)域：Metabolic Enzyme/Protease

作用靶點(diǎn)：Endogenous Metabolite

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參考文獻(xiàn)：

[1]. Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24(1):24.[2]. Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13(1):4981.