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Source

Rabbit

Applications

WB

Reactivity

Human

Dilution

WB 1：500-2000

Storage

-20°C/1 year

Specificity

This antibody detects endogenous levels of 1C04 at Human

Source/Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen

Synthesized peptide derived from human 1C04

Uniprot No

P30504

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008],

Other

HLA-C HLAC, 1C04

Mol.Wt (Da)

40260

Concentration

1 mg/ml