| 概述 |
|
| 描述 | This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation |
| 別名 | CD63抗體;Lysosomal associated membrane protein 3; CD 63; CD63; CD63 antigen (melanoma 1 antigen); CD63 antigen; CD63 antigen melanoma 1 antigen; CD63 molecule; CD63_HUMAN; gp55; Granulophysin; LAMP 3; LAMP-3; LAMP3; LIMP; Lysosomal-associated membrane protein 3; Lysosome associated membrane glycoprotein 3; Mast cell antigen AD1; ME491; Melanoma 1 antigen; Melanoma associated antigen ME491; Melanoma associated antigen MLA1; Melanoma-associated antigen ME491; MGC72893; MLA 1; MLA1; NGA; Ocular melanoma associated antigen; Ocular melanoma-associated antigen; OMA81H; PTLGP40; Tetraspanin 30; Tetraspanin-30; Tspan 30; Tspan-30; TSPAN30; |
| 宿主 | Rabbit anti-CD63 Polyclonal Antibody Rabbit |
| 特異性 | CD63 antibody detects endogenous levels of total CD63. |
| 反應(yīng)種屬 | Human;Mouse;Rat |
| 應(yīng)用 | WB 1:500-1:2000, IHC 1:50-1:200, IF 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
| 免疫原 | A synthesized peptide derived from Human CD63(Accession P08962), corresponding to amino acid residues A148-T174. |
| 性能 |
|
| 濃度 | Rabbit anti-CD63 Polyclonal Antibody 1mg/ml |
| 純化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| 類型 | Polyclonal Antibody |
| 儲存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| 存儲溶液 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 靶標(biāo) |
|
| 背景說明 | Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. |
| 組織特異性 | Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. |
| 翻譯后修飾 | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). |
| 細(xì)胞定位 | Endosome;Extracellular region or secreted;Lysosome;Plasma Membrane; |
| UniProt | P08962 |
| 實(shí)驗(yàn)結(jié)果圖 |
|
| Western blot analysis of CD63 expression in Human platelet lysate;The lane on the left is treated with the antigen-specific peptide. |
| 溫馨提示：本產(chǎn)品僅作科研實(shí)驗(yàn)使用，不支持臨床等研究 |
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